| Seiyuu | Role |
| Kappei Yamaguchi | Inu Yasha |
| Satsuki Yukino | Kagome Higurashi |
| Kouji Tsujitani | Miroku |
| Kumiko Watanabe | Shippo |
| Houko Kuwashima | Sango |
| Ken Narita | Sesshoumaru |
| Toshiyuki Morikawa | Naraku |
| Noriko Hidaka | Kikyo |
| Taiki Matsuno | Kouga |
| Yuichi Nagashima | Jaken |
| Ai Kobayashi | Hakudoushi |
| Yukana Nogami | Kanna |
| Yuuji Ueda | Hojo |
| Mamiko Noto | Rin |
| Hiroaki Hirata | Suikotsu |
| Hisako Kyouda | Kaede |
| Kenichi Ogata | Myouga |
| Akiko Nakagawa | Sota (Kagome's Brother) |
| Asako Dodo | Mama (Kagome's Mother) |
| Ginzou Matsuo | Kagome's Grandfather (only up to Episode 38) |
| Toshihiko Nakajima | Hachiemon |
| Hiroshi Yanaka | Previous Naraku / Onigumo |
| Jouji Yanami | Toutousai |
| Daisuke Kishio | Hakkaku |
| Kaori Shimizu | Yuka |
| Tomokazu Sugita | Renkotsu |
| Masahiko Tanaka | Sango's Father |
| Ai Orikasa | Jakotsu |
| Takeshi Kusao | Bankotsu |
| Hiroyuki Yoshino | Ginta |
| Akiko Yajima | Kohaku |
| Katsumi Suzuki | Kagome's Grandfather (starting with Episode 47) |
| Yuki Masuda | Eri |
| Daisuke Gouri | Kyoukotsu |
| Hisao Egawa | Ginkotsu |
| Tetsu Inada | Mukotsu |
| Saeko Shimazu | Abi-hime |
| Masayo Kurata | Sayo (Episode 22) |
| Fumiko Orikasa | Nazuna (Episode 13) |
| Fumiko Orikasa | Sara-hime (Episode 133) |
| Kiyoyuki Yanada | Rouyakan |
| Kikuko Inoue | Inu Yasha's Mother (Episode 5, 6 & Movie 3) |
| Akira Ishida | Nobunaga Amari (Episode 8) |
| Ryoka Yuzuki | Tsuyu-hime (Episode 8) |
| Wakana Yamazaki | Suzuna (Episode 59) |
| Yumi Kakazu | Ayame (Episode 83, 84, 102) |
| Yumi Ichihara | Satsuki (Episode 55) |
| Nobutoshi Hayashi | Hiten (Episode 9 & 10) |
| Yuri Shiratori | Koume (Episode 91) |
| Reiko Takagi | Mizuki (Episode 130) |
| Motoko Kumai | Hiyoshimaru (Nobunaga's Monkey) |
| Fumihiko Tachiki | Toad Spirit (Episode 8, 94, 95) |
| Junko Noda | Bunza (Episode 72) |
| Motoko Kumai | Gon (Episode 88) |
| Yumiko Kobayashi | Bun (Episode 88) |
| Kaori Shimizu | Ken (Episode 88) |
| Mitsuki Saiga | Shintarou (Episode 112, 113, 125) |
| Ken Yamaguchi | Shintarou's Father (Episode 112) |
| Etsuko Kozakura | Ippou (Episode 130) |
| Kaori Shimizu | Shihou (Episode 130) |
| Rie Kugimiya | Gohou (Episode 130) |
| Sayaka Ohara | Wakana (Episode 131 & 132) |
| Yuri Amano | Tsukiyomi (Episode 139 & 140) |
| Kazuya Nakai | Hoshiyomi (Episode 137 - 140) |
| Tetsu Inada | Manten (Episode 9 & 10) |
| Kaoru Morota | Hiten's Girlfriend (Episode 9) |
| Ayaka Saitou | Mayu (Episode 12) |
| Susumu Chiba | Gozu (Episode 145) |
| Tadahisa Saizen | Bunza's Father (Episode 72) |
| Takehito Koyasu | Gatenmaru (Episode 51, 52, 100) |
| Kazuhiko Inoue | Ryuukotsusei (Episode 53 & 54) |
| Miho Yamada | Tsubaki (Episode 60 - 64) |
| Chinami Nishimura | Botan (Episode 63 & 64) |
| Shiho Kikuchi | Momiji (Episode 63 & 64) |
| Yuko Mizutani | Souten (Episode 68) |
| Ikue Ohtani | Kouryuu (Episode 68) |
| Kaori Mizuhashi | Shiori (Episode 73 & 74) |
| Yuriko Yamaguchi | Shiori's Mother (Episode 73 & 74) |
| Yumi Touma | Touran (Episode 75 - 77) |
| Masaya Takatsuka | Shuuran (Episode 75 - 77) |
| Mitsuru Miyamoto | Kuranosuke Takeda (Episode 78) |
| Tomoko Kawakami | Hari (1st Movie) |
| Naomi Wakabayashi | Kosuke (Episode 94 & 95) |
| Yuki Masuda | Shunran (Episode 75 - 77) |
| Rieko Takahashi | Miroku (as a child Episode 28) |
| Masako Katsuki | Real Suijin (Episode 27) |
| Motoko Kumai | Taroumaru (Episode 27) |
| Junko Noda | Suekichi (Episode 27) |
| Masaharu Satou | Nanushi (Episode 27) |
| Tomokazu Seki | Menoumaru (1st Movie) |
| Hiroko Taguchi | Serina (Episode 59) |
| Takashi Kondou | Kisuke (Episode 129) |
| Fumiko Orikasa | Enju (Episode 92) |
| Seiji Sasaki | Kawaramaru (Episode 92) |
| Ryusuke Ohbayashi | Fake Suijin (Episode 27) |
| Hisao Egawa | Jinenji (Episode 31 & 96) |
| Hekiru Shiina | Ruri (1st Movie) |
| Rei Igarashi | Centipede Woman (Episode 1, 3, 145, 147) |
| Akiko Yajima | Hair Demon Yura (Episode 3 - 5) |
| Masaharu Satou | Goshinki (Episode 43 & 53) |
| Takeshi Aono | Kaijinbo (Episode 44 & 45) |
| Takumi Yamazaki | Kageromaru & Juromaru (Episode 46) |
| Toshihiko Seki | Garamaru (Episode 100) |
| Yuuko Minaguchi | Koyuki (Episode 101) |
| Masaki Terasoma | Goryoumaru (Episode 166 & 167) |
| Sawa Ishige | Chiyo (Episode 108, 109, 113, 115, 116) |
| Nobutoshi Hayashi | Ryuura (4th Movie) |
| Nobuo Tobita | Kyoura (4th Movie) |
| Takeshi Kusao | Juura (4th Movie) |
| Tadahisa Saizen | Goura (4th Movie) |
| Fumiko Orikasa | Asagi (4th Movie) |
| Yuu Kobayashi | Dai (4th Movie) |
| Reiko Kiuchi | Roku (4th Movie) |
| Kaori Shimizu | Shion (4th Movie) |
| Yuki Masuda | Moegi (4th Movie) |
| Emi Motoi | Ai (4th Movie) |
| Akio Ohtsuka | Inu Yasha's Father (3rd Movie) |
| Motoki Takagi | Miroku (as a child Episode 100 & 101) |
| Akira Tomisaka | Hitomi (Episode 90) |
| Natsuko Kuwatani | Shima (Episode 161) |