| Seiyuu | Role |
| Yuko Satou | You Asakura |
| Megumi Hayashibara | Anna Kyouyama |
| Yui Horie | Jeanne |
| Akimitsu Takase | Marco |
| Michiko Neya | Tao Jun |
| Tomoko Kawakami | Pirica |
| Rumi Ochiai | Sharona |
| Makoto Tsumura | Elly |
| Nana Mizuki | Tamao Tamamura |
| Minami Takayama | Hao |
| Yui Horie | Lilly |
| Kazuhiro Nakata | Karim |
| Hikaru Midorikawa | Silver |
| Takeshi Aono | Youmei Asakura |
| Katsuyuki Konishi | Amidamaru |
| Masahiko Tanaka | Bokutou no Ryuu |
| Yuuji Ueda | Horohoro |
| Yoko Soumi | Lyserg |
| Takehito Koyasu | Faust |
| Motoko Kumai | Chocolove |
| Romi Paku | Tao Ren |
| Wataru Takagi | Tokagerou |
| Shinpachi Tsuji | Bason |
| Kentarou Itou | Nichrome (Episode 50, 57, 59, 60) |
| Akiko Hiramatsu | Nyorai (Episode 50) |
| Yuriko Fuchizaki | Melos (Episode 49) |
| Jouji Nakata | Ados (Episode 49 & 63) |
| Fumihiko Tachiki | Ronny (Episode 48) |
| Kikuko Inoue | Anis (Episode 47) |
| Toshihiko Seki | Haloun (Episode 47) |
| Hisao Egawa | Kajimahide (Episode 43 & 44) |
| Susumu Chiba | Pino (Episode 43, 44, 62 - 64) |
| Masako Katsuki | Zorya (Episode 43 & 44) |
| Mika Doi | You's Mother (Episode 42) |
| Mitsuaki Madono | Peyote (Episode 37, 57, 59, 60) |
| Yuko Kobayashi | Fudou (Episode 51 & 54) |
| Wakana Yamazaki | Gekkou (Episode 51 & 54) |
| Yoshihisa Kawahara | Silversun (Episode 10) |
| Seiji Sasaki | Bunstar (Episode 42, 55 - 58) |
| Sayuri | Maia (Episode 49) |
| Shinji Kawada | Death Machine (Episode 10 & 11) |
| Susumu Chiba | Blue Chateau (Episode 1, 8, 10 - 12) |
| Takehito Koyasu | Junk Food (Episode 1, 10 - 12) |
| Yuuji Ueda | Ball Boy (Episode 1, 3, 4, 8, 10, 11) |
| Nobutoshi Hayashi | Muscle Punch (Episode 1, 3, 4, 10 - 12, 25) |
| Susumu Chiba | Zinc (Episode 57 - 60) |
| Megumi Hayashibara | Opacho |
| Miyako Itou | Milly |
| Michiko Neya | Marion (Episode 39, 41, 61) |
| Hidekatsu Shibata | Tao Ching (Episode 23 & 24) |
| Masaya Onosaka | Ryou (Episode 21, 28, 37, 43) |
| Nobuyuki Hiyama | Zen (Episode 21, 28, 37, 43) |
| Masashi Ebara | Tao En (Episode 3, 4, 8, 20 - 24) |
| Shinji Kawada | Silvershield (Episode 13, 16, 19, 20) |
| Kumiko Watanabe | Mosuke (as a child Episode 11 & 12) |
| Hisao Egawa | Mosuke (Episode 2, 12, 51, 58, 62) |
| Mitsuki Saiga | Amidamaru (as a child Episode 11 & 12) |
| Nana Mizuki | Kororo |
| Kenyuu Horiuchi | Mikihisa Asakura |
| Naomi Shindou | Lyserg's Mother (Episode 28) |
| Shinichirou Miki | Chrysler (Episode 30) |
| Kinryu Arimoto | Gus (Episode 31) |
| Tomoe Hanba | Matilda (Episode 39, 41, 61) |
| Mami Koyama | Lililala (Episode 38) |
| Tomoko Kawakami | Miine (Episode 35, 36, 42, 54 - 56) |
| Hisako Kyouda | Kino Asakura (You's Grandmother) |
| Yuko Kaida | China-san (Episode 34) |
| Rumi Kasahara | Kanae (Episode 34) |
| Yuriko Yamaguchi | Tilda (Episode 34) |
| Kouki Miyata | Ashil (Episode 32 & 33) |
| Chika Sakamoto | Alen (Episode 32) |
| Hisako Kyouda | Melanie (Episode 31) |
| Nobutoshi Hayashi | Pailong |